The Journal of Organic Chemistry

Direct formation and subsequent substitution of remote ketone-functionalized organocopper reagents

GW Ebert, WR Klein

Index: Ebert, Greg W.; Klein, Walter R. Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4744 - 4747

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Citation Number: 20

Abstract

Remote ketone-functionalized aryl-and alkylcopper reagents have been synthesized by the use of a highly activated form of zero-valent copper. 5-Bromc-2-pentanone and 4- iodobenzophenone undergo oxidative addition with activated copper to form 5-cuprio- bpentanone and 4-cupriobenzophenone, respectively. These, in turn, can be cross-coupled with alkyl halides to produce the corresponding alkylated ketones and with acid chlorides ...

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