Iron-catalyzed cross-coupling of electron-deficient heterocycles and quinone with organoboron species via innate C–H functionalization: Application in total synthesis …

…, M Yadav, VP Singh, RA Vishwakarma

Index: Singh, Parvinder Pal; Aithagani, Sravan Kumar; Yadav, Mahipal; Singh, Varun Pratap; Vishwakarma, Ram A. Journal of Organic Chemistry, 2013 , vol. 78, # 6 p. 2639 - 2648

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Citation Number: 48

Abstract

Here, we report an iron-catalyzed cross-coupling reaction of electron-deficient heterocycles and quinone with organoboron species via innate C–H functionalization. Iron (II) acetylacetonate along with oxidant (K2S2O8) and phase-transfer catalyst (TBAB) under open flask conditions efficiently catalyzed the cross-coupling of pyrazine with arylboronic acids and gave monoarylated products in good to excellent yields. Optimized conditions ...

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