Angewandte Chemie International Edition

Rhodium??Catalyzed Domino Enantioselective Synthesis of Bicyclo [2.2. 2] lactones

A Boyer, M Lautens

Index: Boyer, Alistair; Lautens, Mark Angewandte Chemie - International Edition, 2011 , vol. 50, # 32 p. 7346 - 7349

Full Text: HTML

Citation Number: 17

Abstract

Increasing focus is placed upon achieving efficiency in processes and syntheses in organic chemistry. The combination of multiple reactions into domino sequences is an excellent way to achieve efficiency, with several operations proceeding in concert without recourse to expensive and wasteful purification at each intermediate stage.[1] The rhodium-catalyzed asymmetric ring-opening (ARO) reaction of strained oxabicyclic alkenes using heteroatom ...