Neurotropic and psychotropic agents. LXIII. 7-Methoxy-10-(4-methylpiperazino) dibenzo [b, f] thiepin and its 10, 11-dihydro derivative
V Bártl, J Metyšová, J Metyš, J Němec…
Index: Bartl; Metysova; Metys; et al. Collection of Czechoslovak Chemical Communications, 1973 , vol. 38, # 8 p. 2301 - 2306
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Citation Number: 6
Abstract
2-(3-Methoxyphenylthio) benzoic acid (VII) was converted in five steps to 7-methoxy-llH- dibenzo [b, fjthiepin-10-one (11). Reaction with I-methylpiperazine and titanium tetrachloride yielded 7-methoxy-1O-(4-methylplperazino) dibenzo [b, fjthiepin (V) which was reduced by diborane to the 10, 11-dihydro derivative I. This compound has a relatively high antihistamine activity while it is a weak central depressant and cataleptic. The enamine V ...
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[Urban, Jiri; Sedivy, Zdenek; Holubek, Jiri; Svatek, Emil; Ryska, Miroslav; et al. Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 4 p. 1077 - 1098]
[Urban, Jiri; Sedivy, Zdenek; Holubek, Jiri; Svatek, Emil; Ryska, Miroslav; et al. Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 4 p. 1077 - 1098]