Tetrahedron Letters

An efficient and chemoselective Brønsted acidic ionic liquid-catalyzed N-Boc protection of amines

S Sunitha, S Kanjilal, PS Reddy, RBN Prasad

Index: Sunitha, Sadula; Kanjilal, Sanjit; Reddy, P. Srinivasa; Prasad, Rachapudi B.N. Tetrahedron Letters, 2008 , vol. 49, # 16 p. 2527 - 2532

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Citation Number: 48

Abstract

The first report of a Brønsted acidic ionic liquid, 1-methylimidazolium tetrafluoroborate [(HMIm) BF4], catalyzed efficient and chemoselective N-Boc protection of various amines using (Boc) 2O is presented. Optically pure amino alcohols and amino acid esters were converted efficiently to their corresponding optically pure N-Boc derivatives. The reported method is mild, solvent-free and has the advantages of both homogeneous and ...

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