Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues

…, N Gretskaya, M Bobrov, V Bezuglov, CJ Hillard…

Index: El Fangour, Siham; Balas, Laurence; Rossi, Jean-Claude; Fedenyuk, Andrey; Gretskaya, Natalia; Bobrov, Mikhail; Bezuglov, Vladimir; Hillard, Cecilia J.; Durand, Thierry Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 12 p. 1977 - 1980

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Citation Number: 7

Abstract

Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both α-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.

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