Catalytic Activation of Silylated Nucleophiles Using tBu??P4 as a Base

M Ueno, C Hori, K Suzawa, M Ebisawa…

Index: Ueno, Masahiro; Hori, Chieko; Suzawa, Koichi; Ebisawa, Masashi; Kondo, Yoshinori European Journal of Organic Chemistry, 2005 , # 10 p. 1965 - 1968

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Citation Number: 10

Abstract

Abstract Trialkylsilyl groups play an important role as effective protecting groups in organic synthesis. Various O, N, and C nucleophilic sites can be protected by trialkylsilyl groups to control the selectivity of reactions. The nucleophilic attack of a fluoride anion on a silyl group is recognized as one of the most useful methods for desilylation. The activation of the nucleophile–silicon bond is important not only for desilylation but also for the generation ...