… : Synthesis of isothiazolo [5, 4-b] quinolines and their oxidation products, 3 [2H]-one-1, 1-dioxideisothiazolo [5, 4-b] quinolines from 2-chloro-3-formylquinolines

A Srivastava, A Chandra…

Index: Srivastava; Chandra, Atish; Singh Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 2 p. 303 - 307

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Citation Number: 2

Abstract

Abstract: A convenient synthesis of isothiazolo [5, 4-b] quinolines 2 is achieved in two steps from the reaction of 2-chloro-3-formylquinolines 1 with sodium sulfide and hydroxylamine sequences followed by cyclisation with acetic anhydride. The subsequent oxidation of 2 with H₂O₂ in acetic acid yields 3 (2H)-one-1, 1-dioxideisothiazolo [5, 4-b] quinolines 3.