Transition metals in organic synthesis, part 91: palladium-catalyzed approach to 2, 6-dioxygenated carbazole alkaloids-first total synthesis of the phytoalexin …

M Schmidt, HJ Knölker

Index: Schmidt, Marika; Knoelker, Hans-Joachim Synlett, 2009 , # 15 p. 2421 - 2424

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Citation Number: 28

Abstract

Our interest in the natural products described above was induced by the carbalexins, described as the first carbazole-containing phytoalexins, [¹5] as well as the pharmacological potential of these compounds. In 2005, Franzblau et al. isolated lansine (5) from Micromelum hirsutum and found that it inhibits the growth of Mycobacterium tuberculosis (strain H 37 Rv). [¹8] In a cooperation with the Franzblau group, we could identify several carbazoles with promising anti-TB ...