Synthesis of vinyl sulfides via hydrothiolation of alkynes using Al 2 O 3/KF under solvent-free conditions

…, JM Marczewski, RG Jacob, EJ Lenardao, G Perin

Index: Silva, Marcio S.; Lara, Renata G.; Marczewski, Junior M.; Jacob, Raquel G.; Lenardao, Eder J.; Perin, Gelson Tetrahedron Letters, 2008 , vol. 49, # 12 p. 1927 - 1930

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Citation Number: 45

Abstract

We present here a clean, solvent-free hydrothiolation of alkynes using solid supported catalyst (Al2O3/KF). This efficient and improved method selectively furnishes the corresponding anti-Markovnikov vinyl sulfides in good to excellent yields. The method is applicable for aliphatic and aromatic thiols and the catalytic system can be re-used up to two times without previous treatment and with comparable activity.

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