Chiral catalysts dually functionalized with amino acid and Zn2+ complex components for enantioselective direct aldol reactions inspired by natural aldolases: design, …

…, M Kitamura, Y Yamada, S Aoki

Index: Itoh, Susumu; Kitamura, Masanori; Yamada, Yasuyuki; Aoki, Shin Chemistry - A European Journal, 2009 , vol. 15, # 40 p. 10570 - 10584

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Citation Number: 28

Abstract

Abstract Aldolases are enzymes that catalyze stereospecific aldol reactions in a reversible manner. Naturally occurring aldolases include class I aldolases, which catalyze aldol reactions via enamine intermediates, and class II aldolases, in which Zn 2+ enolates of substrates react with acceptor aldehydes. In this work, Zn 2+ complexes of L-prolyl-pendant [15] aneN 5 (ZnL 3), L-prolyl-pendant [12] aneN 4 (ZnL 4), and L-valyl-pendant [12] aneN ...