Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine …

D Simoni, J Stoelwinder, AP Kozikowski…

Index: Simoni; Stoelwinder; Kozikowski; Johnson; Bergmann; Ball Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3975 - 3977

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Citation Number: 65

Abstract

Cocaine abuse is one of the greatest concerns of the public today and has therefore become a focus of medical, social, and political leaders.'P2 Currently a number of treatment strategies are being explored using CNS (central nervous system) agents developed for other affliction^.^^^ While these agents appear to depress either self-administration or cocaine “craving” under certain circumstances, these studies are still in their early stages, ...

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