Design, Synthesis, and Pharmacological Characterization of N-and O-Substituted 5, 6, 7, 8-Tetrahydro-4 H-isoxazolo [4, 5-d] azepin-3-ol Analogues: Novel 5-HT2A/5- …

…, P Krogsgaard-Larsen, B Frølund

Index: Krogsgaard-Larsen,P.; Hjeds,H. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1974 , vol. 28, p. 533 - 538

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Citation Number: 15

Abstract

The isoxazol-3-one tautomer of the bicyclic isoxazole, 5, 6, 7, 8-tetrahydro-4 H-isoxazolo [4, 5-d] azepin-3-ol (THAZ), has previously been shown to be a weak GABAA and glycine receptor antagonist. In the present study, the potential in this scaffold has been explored