Methoxyflavone inhibitors of cytochrome P450

M McKendall, T Smith, K Anh, J Ellis, T McGee…

Index: McKendall, Michael; Smith, Tasha; Anh, Kien; Ellis, Jamie; McGee, Terri; Foroozesh, Maryam; Zhu, Naijue; Stevens, Cheryl L. Klein Journal of Chemical Crystallography, 2008 , vol. 38, # 4 p. 231 - 237

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Citation Number: 7

Abstract

Abstract Cytochrome P450 enzymes are a superfamily of enzymes involved in the metabolism of endogenous compounds as well as xenobiotics. Due to the large number of reactions catalyzed by these enzymes and their importance in drug metabolism and carcinogenesis, they have been the focus of many studies over the years. Based on the knowledge that flavones are natural substrates of certain P450 enzymes (such as P450 ...

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