3??Nitro??2H??chromenes as a New Class of Inhibitors against Thioredoxin Reductase and Proliferation of Cancer Cells

…, BX Liang, SH Chen, TM Ou, XZ Bu, M Yan

Index: Xiao, Guo-Qiang; Liang, Bao-Xia; Chen, Shu-Han; Ou, Tian-Miao; Bu, Xian-Zhang; Yan, Ming Archiv der Pharmazie, 2012 , vol. 345, # 10 p. 767 - 770

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Citation Number: 12

Abstract

Abstract A series of 3-nitrochromenes were designed and synthesized. These compounds showed good inhibitory activity against thioredoxin reductase (TrxR) and the proliferation of A549 cancer cells. The structure–activity relationship analysis indicates that the 3- nitrochromene scaffold is the crucial pharmacophore for achieving good inhibitory activity. The bromo-substitutions at the 6-and 8-position of 3-nitrochromene significantly increase ...