Tetrahedron Letters

Efficient ligand-free copper-catalyzed N-arylation of amides with aryl halides in water

FF Yong, YC Teo, GL Chua, GS Lim, Y Lin

Index: Yong, Fui-Fong; Teo, Yong-Chua; Chua, Guan-Leong; Lim, Gina Shiyun; Lin, Yizhen Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1169 - 1172

Full Text: HTML

Citation Number: 18

Abstract

A convenient and efficient protocol has been developed for the cross-coupling of amides and aryl iodides using a ligand-free copper (I) oxide catalyst in water. A variety of amide derivatives afforded the corresponding N-arylated products in moderate to good yields (up to 88%).

Related Articles:

Reformatsky reactions with N-arylpyrrolidine-2-thiones: synthesis of tricyclic analogues of quinolone antibacterial agents

[Michael, Joseph P; De Koning, Charles B; Hosken, Gladys D; Stanbury, Trevor V Tetrahedron, 2001 , vol. 57, # 47 p. 9635 - 9648]

A versatile synthesis of tricyclic analogues of quinolone antibacterial agents: Use of a novel reformatsky reaction

[Michael, Joseph P.; De Koning, Charles B.; Stanbury, Trevor V. Tetrahedron Letters, 1996 , vol. 37, # 52 p. 9403 - 9406]

Conformational analysis of rotational barriers in N-arylpyrrolidin-2-ones

[Billing, D. G.; Boeyens, J. C. A.; Denner, L.; Plooy, K. E. Du; Long, G. C.; Michael, J. P. Acta Crystallographica, Section B: Structural Science, 1991 , vol. 47, # 2 p. 284 - 288]

More Articles...