Total synthesis of (+)-asteltoxin

KD Eom, JV Raman, H Kim, JK Cha

Index: Kim, Heejin; Lee, Suk-Kwan; Lee, Dongreyoul; Cha, Jin Kun Synthetic Communications, 1998 , vol. 28, # 4 p. 729 - 735

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Citation Number: 31

Abstract

A convergent synthesis of (+)-asteltoxin (1) has been achieved by the Horner-Emmons olefination of bis (tetrahydrofuran) aldehyde 53 and α-pyrone phosphonate 5. A key step features the stereoselective construction of a sterically congested quaternary center