Tetrahedron: Asymmetry

Enantioselective total synthesis of both the stereoisomers of dihydrokawain-5-ol

A Kamal, T Krishnaji, PV Reddy

Index: Kamal, Ahmed; Krishnaji, Tadiparthi; Reddy, P. Venkat Tetrahedron Asymmetry, 2007 , vol. 18, # 15 p. 1775 - 1779

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Citation Number: 14

Abstract

The enantioselective synthesis of both the stereoisomers of dihydrokawain-5-ol is described. The key features of the synthetic strategy include (a) Sharpless asymmetric dihydroxylation,(b) Wittig olefination, and (c) formation of β-keto ester to access the highly enantiomerically pure kavalactones.

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