A facile synthesis of an unsymmetric benzopyranobenzopyran ring system

RM Kanojia, N Jain, J Xu, Z Sui

Index: Kanojia, Ramesh M.; Jain, Nareshkumar; Xu, Jiayi; Sui, Zhihua Tetrahedron Letters, 2004 , vol. 45, # 30 p. 5837 - 5839

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Citation Number: 9

Abstract

In conjunction with our medicinal chemistry efforts to discover novel selective estrogen receptor modulators (SERMs), we chose to access the steroid-mimetic scaffold, unsymmetric bisbenzopyran II through the lactone precursor I. To facilitate our SAR studies, we looked for a synthetic method that would allow us to introduce a variety of functional groups into the A-, B-, and D-rings. ... A brief survey of the literature revealed that although the synthesis of symmetrical ...