Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases

BM Lienard, A Conejo-García, I Stolze…

Index: Lienard, Benoit M.; Conejo-Garcia, Ana; Stolze, Ineke; Loenarz, Christoph; Oldham, Neil J.; Ratcliffe, Peter J.; Schofield, Christopher J. Chemical Communications, 2008 , # 47 p. 6393 - 6395

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Citation Number: 16

Abstract

Known and potential aspirinmetabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-α in cells. ... Fig. 1 Potential inhibitors and related compounds used in the study. ... Derivatives of 2 and 3 were synthesised (see ESI† ) to test the possibility that they might be HIF hydroxylase inhibitors (8, 10 and 14–26; Fig. 1). 10 and 24 were of interest, as 10 ...