Tetrahedron letters

Phosphitylation via the Mitsunobu reaction

ID Grice, PJ Harvey, ID Jenkins, MJ Gallagher…

Index: Grice, I. Darren; Harvey, Peta J.; Jenkins, Ian D.; Gallagher, Michael J.; Ranasinghe, Millagahamada G. Tetrahedron Letters, 1996 , vol. 37, # 7 p. 1087 - 1090

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Citation Number: 10

Abstract

Treatment of a dialkyl phosphite with triphenylphosphine and diisopropyl azodicarboxylate in toluene, followed by addition of an alcohol, results in the formation of the corresponding trialkyl phosphite. Similarly, dialkyl phosphonites can be synthesised from monoalkyl phosphites (alkyl phosphinates).