Novel synthesis of flavonoids of Scutellaria baicalensis Georgi.

WH Huang, PY Chien, CH Yang, AR Lee

Index: Huang, Wen-Hsin; Chien, Pei-Yu; Yang, Ching-Huey; Lee, An-Rong Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 3 p. 339 - 340

Full Text: HTML

Citation Number: 63

Abstract

A concise and efficient total synthesis of the flavonoids baicalein, oroxylin A and wogonin was described. Intramolecular oxidative cyclization followed by demethylation of chalcone 1, readily prepared from trimethoxyphenol, afforded, depending upon the controlled conditions, baicalein or oroxylin A in excellent yields. Demethylation of 1 yielded 3, which, by oxidation with I 2/dimethyl sulfoxide (DMSO), was readily converted to oroxylin A and wogonin after ...