Solid??Phase Development of Chiral Phosphoramidite Ligands for Enantioselective Conjugate Addition Reactions

O Huttenloch, E Laxman…

Index: Huttenloch, Oliver; Laxman, Eltepu; Waldmann, Herbert Chemistry - A European Journal, 2002 , vol. 8, # 20 p. 4767 - 4780

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Citation Number: 58

Abstract

Abstract The development of a method for the optimization of chiral ligands for the steric steering of enantioselective Cu-catalyzed conjugate additions of Zn-alkyls to enones is described. The method is based on combinatorial principles and solid-phase techniques. It includes the combinatorial synthesis of chiral bispidine-derived ligands embodying a phosphoramidite group on the solid phase and their investigation in immobilized form in ...