Tetrahedron letters

Polymer-supported triacetoxyborohydride: a novel reagent of choice for reductive amination

S Bhattacharyya, S Rana, OW Gooding, J Labadie

Index: Bhattacharyya, Sukanta; Rana, Sunil; Gooding, Owen W.; Labadie, Jeff Tetrahedron Letters, 2003 , vol. 44, # 27 p. 4957 - 4960

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Citation Number: 20

Abstract

A novel polymer-supported triacetoxyborohydride reagent for reductive amination of aldehydes and ketones is reported. The bound reagent was found to be shelf-stable and provided broad scope and reactivity in reductive amination reactions under mild reaction conditions. Streamlined protocols for its application in reductive amination reactions using both primary and secondary amines are described.

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