Bioorganic & medicinal chemistry letters

QSAR study on antibacterial activity of sulphonamides and derived Mannich bases

S Joshi, N Khosla

Index: Joshi, Sheela; Khosla, Navita Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 21 p. 3747 - 3751

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Citation Number: 35

Abstract

The paper describes synthesis and comparative study on antibacterial activities of sulphonamides and Mannich bases derived from them. The compounds were screened for their antibacterial activity against various gram-positive and gram-negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.