Kinetics and mechanism of chlorine exchange between chloramine??T and secondary amines

H Dannan, PA Crooks, LW Dittert…

Index: Dannan; Crooks; Dittert; Hussain Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 7 p. 652 - 656

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Citation Number: 5

Abstract

Abstract The kinetics and mechanisms of chlorine transfer from chloramine-T (CAT) to several amines are second order and independent of p-toluenesulfonamide concentration; thus, the reaction does not involve disproportionation of CAT to dichloramine-T. From the profile of pH versus rate, the following mechanisms were proposed:(1) reaction of the ionized species of CAT with the ionized amine (ionic mechanism) and (2) reaction of the ...

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