N6-Phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors

MM Kwatra, E Leung, MM Hosey…

Index: Kwatra; Leung; Hosey; Green Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 954 - 956

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Citation Number: 15

Abstract

A number of I\ rs-phenyladenosines with various substitutions on the phenyl ring have been synthesized and tested for their affinities toward brain Al and A2 adenosine receptors. Compounds with meta substituents, such (m-hydroxyand m-iodophenyl) adenosine, were found to have high Al selectivity. Meta substitution caused a selective decrease in the affinity of these compounds for A2 receptors. The results suggest that, in contrast to what is ...