Synthesis and murine antineoplastic activity of bis [carbamoyloxymethyl] derivatives of pyrrolo [2, 1-a] isoquinoline

WK Anderson, HL McPherson Jr, JS New…

Index: Anderson, Wayne K.; McPherson, Howard L.; New, James S.; Rick, Arvela C. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1321 - 1325

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Citation Number: 35

Abstract

The synthesis of 4, 5-dihydropyrrolo [2, la] isoquinolines is reported. A key intermediate in the synthesis of 8-methoxy-4, 5-dihydropyrrolo [2, lu] isoquinolines, 6-hydroxy-l, 2, 3, 4- tetrahydroisoquinoline-l-carboxylic acid (6), was prepared by using a regiospecific phenolic cyclization reaction. The P388 lymphocytic activity is reported for l, 2-bis (hydroxymethy)-5, 6- dihydro-8-methoxy-3-methylpyrrolo [2, 1-a] isoquinoline bis (isopropy1carbamate)(1 la), 1, ...