Efficient solvent-free selective monoalkylation of arylacetonitriles with mono-, bis-, and tris-primary alcohols catalyzed by a Cp* Ir complex

C Löfberg, R Grigg, MA Whittaker, A Keep…

Index: Loefberg, Christian; Grigg, Ronald; Whittaker, Mark A.; Keep, Ann; Derrick, Andrew Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8023 - 8027

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Citation Number: 69

Abstract

Our objectives were to develop catalytic atom-economic processes accessing and/or incorporating versatile functionality using aryl/heteroaryl acetonitriles as substrates. We report essentially solvent-free [Cp* IrCl2] 2 catalyzed redox neutral processes whereby substituted acetonitriles react with primary alcohols to deliver monosubstituted aryl/heteroaryl acetonitriles in excellent yield. We further demonstrate that such processes ...

Inhibitors of acyl CoA: cholesterol acyltransferase

[Vaccaro, Wayne; Amore, Cindy; Berger, Joel; Burrier, Robert; Clader, John; Davis, Harry; Domalski, Martin; Fevig, Tom; Salisbury, Brian; Sher, Rosy Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1704 - 1719]

Reduction of. alpha.,. beta.-diarylacrylonitriles by sodium borohydride

[Kulp, Stuart S.; Caldwell, Craig B. Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 171 - 173]

Inhibitors of acyl CoA: cholesterol acyltransferase

Efficient solvent-free selective monoalkylation of arylacetonitriles with mono-, bis-, and tris-primary alcohols catalyzed by a Cp* Ir complex

Abstract

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