Development of a Catalytic Platform for Nucleophilic Substitution: Cyclopropenone??Catalyzed Chlorodehydration of Alcohols

CM Vanos, TH Lambert

Index: Vanos, Christine M.; Lambert, Tristan H. Angewandte Chemie - International Edition, 2011 , vol. 50, # 51 p. 12222 - 12226

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Citation Number: 33

Abstract

The nucleophilic substitution of alcohols is one of the most commonly executed and strategically important transformations in organic chemistry.[1] These reactions have long been used to transfer the structural and stereochemical complexity of alcohols to a myriad of other products.[2] Despite this importance, the traditional reagents for alcohol substitution leave much to be desired. Such reagents often produce problematic by-products or suffer ...

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