The design, synthesis, and anti-tumor mechanism study of N-phosphoryl amino acid modified resveratrol analogues

…, A Dong, C Gao, C Tan, H Liu, X Zu, Y Jiang

Index: Liu, Huachen; Dong, Aijun; Gao, Chunmei; Tan, Chunyan; Liu, Hongxia; Zu, Xuyu; Jiang, Yuyang Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10013 - 10021

Full Text: HTML

Citation Number: 31

Abstract

A novel series of trans-N-phosphoryl amino acid modified resveratrol analogues were synthesized and evaluated in vitro for their cytotoxic effects against CNE-1 and CNE-2 cell lines. These analogues showed good anti-proliferative activity, among which 8d, 8e, 8j, and 9d displayed much stronger inhibition effect than resveratrol and 8d showed the most potent activity with IC50 value at 3.45±0.82 μM. The anti-tumor effects of 8d, 8e, 8j, and 9d were ...

Related Articles:

Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer

[Sun, Bin; Hoshino, Juma; Jermihov, Katie; Marler, Laura; Pezzuto, John M.; Mesecar, Andrew D.; Cushman, Mark Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5352 - 5366]

Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines

[Roberti, Marinella; Pizzirani, Daniela; Simoni, Daniele; Rondanin, Riccardo; Baruchello, Riccardo; Bonora, Caterina; Buscemi, Filippo; Grimaudo, Stefania; Tolomeo, Manlio Journal of Medicinal Chemistry, 2003 , vol. 46, # 16 p. 3546 - 3554]

Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines

[Roberti, Marinella; Pizzirani, Daniela; Simoni, Daniele; Rondanin, Riccardo; Baruchello, Riccardo; Bonora, Caterina; Buscemi, Filippo; Grimaudo, Stefania; Tolomeo, Manlio Journal of Medicinal Chemistry, 2003 , vol. 46, # 16 p. 3546 - 3554]

Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease

[Lu, Chuanjun; Guo, Yueyan; Yan, Jun; Luo, Zonghua; Luo, Hai-Bin; Yan, Ming; Huang, Ling; Li, Xingshu Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5843 - 5859]

Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease

[Lu, Chuanjun; Guo, Yueyan; Yan, Jun; Luo, Zonghua; Luo, Hai-Bin; Yan, Ming; Huang, Ling; Li, Xingshu Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5843 - 5859]

More Articles...