Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease

C Lu, Y Guo, J Yan, Z Luo, HB Luo, M Yan…

Index: Lu, Chuanjun; Guo, Yueyan; Yan, Jun; Luo, Zonghua; Luo, Hai-Bin; Yan, Ming; Huang, Ling; Li, Xingshu Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5843 - 5859

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Citation Number: 65

Abstract

A series of multitarget-directed resveratrol derivatives was designed and synthesized for the treatment of Alzheimer's disease (AD). In vitro studies indicated that most of the target compounds exhibit significant inhibition of self-induced β-amyloid (Aβ) aggregation and Cu (II)-induced Aβ1–42 aggregation and acted as potential antioxidants and biometal chelators. In particular, compounds 5d and 10d are potential lead compounds for AD therapy (5d, ...

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