Absolute configuration determination of 2-(2-oxo-3-indolyl) acetamide derivatives

OR Suárez-Castillo, M Meléndez-Rodríguez…

Index: Suarez-Castillo, Oscar R.; Melendez-Rodriguez, Myriam; Castelan-Duarte, Luis Enrique; Sanchez-Zavala, Maricruz; Rivera-Becerril, Ernesto; Morales-Rios, Martha S.; Joseph-Nathan, Pedro Tetrahedron Asymmetry, 2009 , vol. 20, # 20 p. 2374 - 2389

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Citation Number: 14

Abstract

We describe a reliable method for determining the absolute configuration of 2-(2-oxo-3- indolyl) acetamides based on analysis of the 1H NMR spectra of their phenylethylamide diastereomers. The conformational preferences for two diastereomeric amides were calculated by DFT, which matched well with the experimental results. X-ray diffraction analysis allowed us to validate the method.

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