Synthesis and antiinflammatory activity of some 1, 6-methano [10] annuleneacetic acids

PH Nelson, GA Bartsch, KG Untch…

Index: Nelson; Bartsch; Untch; Fried Journal of Medicinal Chemistry, 1975 , vol. 18, # 6 p. 583 - 586

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Citation Number: 6

Abstract

17-Hydroxy-3-methoxy-19-nor-17a-pregna-1, 3, 5 (10), 20-te-traene-2021-dicarboxylic Acid Anhydride (6). An 8 N chromic acid solution (6.55 ml) was added slowly to a solution of 3a (500 mg) in acetone (25 ml) at 10-12O. After stirring for 15 min at room temperature, the excess oxidant was decomposed by the addition of i-PrOH. H20 was added and the solution was evaporated almost to dryness. The residue was extracted with Et20 and CH2C12. ...

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