Antiviral activity of arylnaphthalene and aryldihydronaphthalene lignans
C Cow, C Leung, JL Charlton
Index: Cow, Christopher; Leung, Carmen; Charlton, James L. Canadian Journal of Chemistry, 2000 , vol. 78, # 5 p. 553 - 561
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Citation Number: 52
Abstract
A practical method for large scale synthesis of 1-arylnaphthalene and 1-aryl-1, 2- dihydronaphthalene lignans is described. The method makes use of the classic Stobbe condensation followed by regioselective reactions that provide access to both the common and retrolactone lignans, eg, 2 and 3. A total of 25 compounds, many of which are known natural products, were prepared and their antiviral activity against human cytomegalovirus ...
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