Dimerization of butenolide structures. A biomimetic approach to the dimeric sesquiterpene lactones (±)-biatractylolide and (±)-biepiasterolide

…, RM Adlington, JE Baldwin, R Marquez

Index: Bagal, Sharanjeet K.; Adlington, Robert M.; Baldwin, Jack E.; Marquez, Rodolfo Journal of Organic Chemistry, 2004 , vol. 69, # 26 p. 9100 - 9108

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Citation Number: 46

Abstract

The biomimetic synthesis of the bisesquiterpene lactones (±)-biatractylolide 1 and (±)- biepiasterolide 2 via dimerization of the captodative stabilized radical 8 is reported. Atractylon 7 has also been shown to be a possible intermediate during the biosynthesis of biatractylolide 1, biepiasterolide 2, atractylolide 3, and hydroxyatractylolide 4.