Tetrahedron letters

A highly efficient enantioselective synthesis of 2-methyl chromans via four sequential palladium-catalyzed reactions

M Palucki, N Yasuda

Index: Palucki, Michael; Yasuda, Nobuyoshi Tetrahedron Letters, 2005 , vol. 46, # 6 p. 987 - 990

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Citation Number: 13

Abstract

An enantioselective synthesis of substituted 2-methyl chromans was accomplished in four steps using four sequential Pd-catalyzed reactions. A study of the key palladium-catalyzed regioselective aryl ether ring formation of two different substrates was also carried out to better understand the factors which affect the selectivity of the reaction.