Tetrahedron: Asymmetry

Catalytic enantioselective synthesis of macrolides via asymmetric alkylation

GB Jones, RS Huber, BJ Chapman

Index: Jones, Graham B.; Huber, Robert S.; Chapman, Brant J. Tetrahedron Asymmetry, 1997 , vol. 8, # 11 p. 1797 - 1809

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Citation Number: 56

Abstract

Catalytic enantioselective syntheses of the macrolides (R)-(−) phoracantholide and (R)-(+) lasiodiplodin have been achieved. Stereochemistry was introduced in using an arene chromium tricarbonyl derived catalyst, which mediated the enantioselective addition of dimethyl zinc to a functionalized aldehyde.

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