Organic letters

Carbonylative sonogashira coupling of terminal alkynes with aqueous ammonia

MS Mohamed Ahmed, A Mori

Index: Mohamed Ahmed, Mohamed S.; Mori, Atsunori Organic Letters, 2003 , vol. 5, # 17 p. 3057 - 3060

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Citation Number: 127

Abstract

Carbonylative coupling of phenylethyne with 4-methoxy-1-iodobenzene in the presence of 1 mol% PdCl2 (PPh3) 2, 2 equiv of 0.5 M aqueous ammonia, and CO (1 atm) gives the corresponding α, β-alkynyl ketone in 72% isolated yield after stirring at room temperature for 41 h, while noncarbonylative coupling product is not obtained.

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