Pyrazolone Derivatives: Synthesis, Anti-inflammatory, Analgesic, Quantitative Structure–Activity Relationship and in Vitro Studies

FAF Ragab, NM Abdel-Gawad, HH Georgey…

Index: Ragab, Fatma Abdel-Fattah; Abdel-Gawad, Nagwa Mohamed; Georgey, Hanan Hanna; Said, Mona Fikry Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 8 p. 834 - 845

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Citation Number: 6

Abstract

Some 1-(4-chlorophenyl or benzenesulfonamide)-2, 3-and/or 4-substituted-1H-pyrazol-5 (4H)-one derivatives were synthesized and screened for their anti-inflammatory and analgesic activities, in addition to their ulcerogenic liability. They were found to be active as anti-inflammatory and analgesic agents. Compound 6b was found to be the most active as anti-inflammatory agent and compound 9b was found to be the most active one as anti- ...