Cu (II)-Catalyzed Aerobic Hydroperoxidation of Meldrum's Acid Derivatives and Application in Intramolecular Oxidation: A Conceptual Blueprint for O2/H2 …

SW Krabbe, DT Do, JS Johnson

Index: Krabbe, Scott W.; Do, Dung T.; Johnson, Jeffrey S. Organic Letters, 2012 , vol. 14, # 23 p. 5932 - 5935

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Citation Number: 10

Abstract

Aerobic hydroperoxidation of Meldrum's acid derivatives via a Cu (II)-catalyzed process is presented. The mild reaction conditions are tolerant to pendant unsaturation allowing the formation of endoperoxides via electrophilic activation. Cleavage of the O–O bond provides 1, n-diols with differentiation of the hydroxy groups.