Romazarit. A potential disease-modifying antirheumatic drug

…, JC Wickens, DP Bloxham, D Bradshaw

Index: Self; Barber; Machin; Osbond; Smithen; Tong; Wickens; Bloxham; Bradshaw; Cashin; Dodge; Lewis; Westmacott Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 772 - 777

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Citation Number: 20

Abstract

The disease modifying antirheumatic drugs (DMARDs) which are available in current clinical practice are considerably limited by their narrow therapeutic ratio and by the severity of their side effects. l Therefore there is a demonstrable need for DMARDs of increased potency coupled with reduced adverse effects. The development of such agents by rational means has been hampered by the paucity of detailed information on the mechanisms of action of ...