Regio-selective hydroxylation of gem-difluorinated octanes by alkane hydroxylase (AlkB)
R Ramu, CW Chang, HH Chou, LL Wu, CH Chiang…
Index: Ramu, Ravirala; Chang, Chun-Wei; Chou, Ho-Husan; Wu, Li-Lan; Chiang, Chih-Hsiang; Yu, Steve S.-F. Tetrahedron Letters, 2011 , vol. 52, # 23 p. 2950 - 2953
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Abstract
Abstract gem-Difluoromethylene substituted molecules constitute a distinct class of fluorinated compounds. In this study, special chemistry has been developed for their preparation based on the highly selective terminal hydroxylation of these gem-difluorinated octanes by AlkB (alkane hydroxylase) from Pseudomonas putida Gpo1 to form gem- difluorinated octan-1-ols. The hydroxylation reaction is performed by whole-cell catalysis. ...
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