Ruthenium-and rhodium-catalyzed direct carbonylation of the ortho CH bond in the benzene ring of N-arylpyrazoles

…, T Fukuyama, Y Ie, F Kakiuchi, N Chatani

Index: Asaumi, Taku; Matsuo, Takuya; Fukuyama, Takahide; Ie, Yutaka; Kakiuchi, Fumitoshi; Chatani, Naoto Journal of Organic Chemistry, 2004 , vol. 69, # 13 p. 4433 - 4440

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Citation Number: 56

Abstract

The direct carbonylation of CH bonds in the benzene ring of N-phenylpyrazoles via catalysis by ruthenium or rhodium complexes is described. The reaction of N-phenylpyrazoles with carbon monoxide and ethylene in the presence of Ru3 (CO) 12 or Rh4 (CO) 12 resulted in the site-selective carbonylation of the ortho CH bonds in the benzene ring to give the corresponding ethyl ketones. A variety of functional groups on the benzene ring can be ...