1-Azaspiro Annelation: A Synthetic Approach to Naturally Occurring Heterocyclic Spiranes

TA Bryson, CA Wilson

Index: Bryson,T.A.; Wilson,C.A. Synthetic Communications, 1976 , vol. 6, p. 521 - 526

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Citation Number: 7

Abstract

Abstract The synthesis of 1-azaspiro [4, 4] nonans,-[4, 5] decanes and-[5, 5] undecanes has attracted considerable attention in recent years with special interest in natural products such as histrionacotoxin, 1 serratinine2 and harringtonine. 3 We have been investigating several synthetic approaches to these systems in hopes of developing one general approach to all such compounds. We were particularly interested in simplicity and chose to utilize a ...