Δ9-Tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled Δ9-tetrahydrocannabinol

L Qi, N Yamamoto, MM Meijler, LJ Altobell…

Index: Qi, Longwu; Yamamoto, Noboru; Meijler, Michael M.; Altobell III, Laurence J.; Koob, George F.; Wirsching, Peter; Janda, Kim D. Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7389 - 7399

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Citation Number: 13

Abstract

Immunopharmacotherapy as an approach to combat drugs of abuse has become an active area of investigation. Marijuana is the most commonly used illicit drug in the US The main active chemical in marijuana is Δ9-tetrahydrocannabinol (Δ9-THC); hence, monoclonal antibodies with high affinity and specificity for Δ9-tetrahydrocannabinol could be valuable immunopharmacotherapeutic intervention and diagnostic tools. We have synthesized ...