Tetrahedron Letters

Claisen ortho ester rearrangement with trimethyl β-(methoxy) orthopropionate: a thermally stable synthon for the preparation of methyl α-substituted acrylates

S Raucher, JE Macdonald, RF Lawrence

Index: Raucher, Stanley; Macdonald, James E.; Lawrwence, Ross F. Tetrahedron Letters, 1980 , vol. 21, # 45 p. 4335 - 4338

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Citation Number: 10

Abstract

Abstract Trimethyl β-(methoxy) orthopropionate, a compound which is thermally stable at 190 C for prolonged times, may be utilized as a synthon for the preparation of methyl α- substituted acrylates via Claisen ortho ester rearrangement with allylic alcohols followed by β-elimination of methanol with base.