Metal catalyst-free amination of 2-chloro-5-nitrobenzoic acid in superheated water
C Lan, ZN Xia, ZH Li, RH Liang
Index: Lan, Cong; Xia, Zhi-Ning; Li, Zheng-Hua; Liang, Rong-Hui Journal of Chemical Research, 2012 , vol. 36, # 12 p. 726 - 728
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Abstract
A series of N-arylanthranilic acid derivatives were synthesised by amination of 2-chloro-5- nitrobenzoic acid with various arylamine in superheated water with potassium carbonate as base. Good yields were achieved within 2–3 h at 150–190° C. The results indicated that this metal catalyst-free method is a simple, environmentally-friendly and efficient synthesis of N- phenylanthranilic acid derivatives. Furthermore, it will work with an alkylamine and phenol.
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