Synthesis and crystallographic analysis of benzophenone derivatives—The potential anti-inflammatory agents

TD Venu, S Shashikanth, SA Khanum, S Naveen…

Index: Venu; Shashikanth; Khanum; Naveen; Firdouse, Aiysha; Sridhar; Shashidhara Prasad Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 10 p. 3505 - 3514

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Citation Number: 25

Abstract

Fries rearrangement of substituted phenyl benzoates 1a–j to substituted hydroxy benzophenones 2a–j was achieved in excellent yield. Further benzoylation of 2a–j to benzoyloxy benzophenones 4a–n, a benzophenone analogue was achieved in good yield. All the newly synthesized compounds were evaluated for their anti-inflammatory activity and were compared with standard drugs. Out of the compounds studied, the compounds 4c, ...

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