General method for the preparation of functionalized fluorinated phenyl alkynes

BV Nguyen, ZY Yang, DJ Burton

Index: Nguyen, Ba V.; Yang, Zhen-Yu; Burton, Donald J. Journal of Organic Chemistry, 1993 , vol. 58, # 26 p. 7368 - 7376

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Citation Number: 26

Abstract

In the presence of cuprous iodide, the palladium-catalyzed coupling reaction of 4-substituted tetrafluorophenyl iodides 1 with terminal alkynes proceeds readily in diisopropylamine or triethylamine to afford the corresponding fluorinated phenylalkynes in excellent yields under mild conditions. A variety of substituents on F-benzenes such as methoxy, dimethylamino, hydro, acyl, piperidino, and morpholino do not interfere with the coupling reaction. The ...